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156-158 A number of factors influence the potential for a drug to be ototoxic, such as dosage and duration of treatment, lifetime dose, kidney function, and simultaneous use of multiple ototoxic medications
Subgroup analyzes were performed by study phase (early phase [Phase 1, Phase 1/2, Phase 2] vs late phase [Phase 2/3, Phase 3, Phase 4]) and by study drug (semaglutide, tirzepatide, liraglutide, dulaglutide, exenatide, lixisenatide, and others)
Benefits Beyond Weight Loss: Metabolic and Cardiovascular Health Cardiovascular risk reduction semaglutide reduced major cardiovascular events by 20% in the SELECT trial Blood sugar control significant HbA1c reductions in patients with type 2 diabetes or prediabetes Reduced liver fat growing evidence supports GLP-1 therapy for NAFLD and MASLD Sleep apnea improvement tirzepatide demonstrated 63% reduction in apnea-hypopnea index (2024 NEJM trial) Fatty Liver Disease & GLP-1 Therapy Patients with NAFLD/MASLD may see significant improvement with GLP-1 treatment
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Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells
Reduced Nutrient Intake Because GLP-1 medications suppress appetite, some individuals consume fewer calories and less protein than the body requires for normal hair production
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