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This is not a replacement for trials, but it can move much faster, and that speed matters when a drug goes from niche to mainstream almost overnight. A major challenge in this process, which Guntuku calls computational social listening, has been scale
Improves blood sugar control and reduces cardiovascular risk
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Decreased BDNF in the hippocampus and PFC has been noted in depressed patients (Krishnan and Nestler, 2008
The dual-action setup might explain why it has been pulling ahead in some studies
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