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4.3.1 Acetylcholine Acetylcholine (ACh), the primary excitatory neurotransmitter of ENS cholinergic neurons, is synthesized by choline acetyltransferase (ChAT) and modulates GI functions through muscarinic receptors (M2/M3)
10.1038/s41598-018-19213-4 128 SeibtT
It has a high affinity to GLP-1R, strongly activating the GLP-1R Gs cAMP pathway without inducing measurable -arrestin recruitment signaling, which indicates it is a fully biased agonist
7b-c, 0.89 0.06 vs
Other actions of GLP-1 that also contribute to restoring glucose regulation in Type 2 diabetes include inhibition of glucagon secretion, slowing of gastric emptying, suppression of appetite and modest reduction in body weight (37, 48, 84, 118)
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