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This metabolic imbalance was linked to progressive motor dysfunction

To evaluate Dihexas ability to cross the BBB and accumulate in brain regions, rats were fitted with carotid cannulas and infused with a mixture of [H]Dihexa (10 Ci) and [C]inulin (2 Ci), a vascular space marker, in 100 l of isotonic saline

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Protein structure comparison showed that SsCm1 was obviously different from other Cms in three-dimensional structure, and molecular docking simulation revealed that SsCm1 showed less affinity with chorismate (binding energy = 2.1 kcal/mol) than ScAro7 (5.7 kcal/mol) (Supplementary Fig

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