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Finding potential use for NMDA antagonists as anesthetic agents, PCP was introduced for this use but had untoward side effects, and was quickly replaced by the non-competitive NMDA antagonist, ketamine
It is used in "Phase II" detoxification, where it binds to toxins to make them water-soluble so they can be filtered out of the body
Skimping on sleep undermines IGF-1 LR3's potential effects
VD exerts antiepileptic effects by modulating the gut microbiota Emerging evidence suggests that VD suppresses the NF-kB p65-mediated MLCK-P-MLC signaling pathway via direct VDR-transforming growth factor--activated kinase 1 (TAK1) interactions, thereby ameliorating the altered localization of TJ proteins and preserving tight junction continuity in colonic organoids [107]
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