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44.2% non-Hispanic white) matched by propensity score based on GLP-1 receptor agonist users (n = 43,317) and nonusers (n = 43,315)

Individual speakers at a 2024 National Academies workshop suggested that GLP-1R agonists may reach the brain mainly through specialised uptake at the circumventricular organs, regions that sit outside the standard barrier, rather than by penetrating it

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When they detect a threat, whether an allergen, an infection signal, or a physical stimulus, they release a burst of histamine into the surrounding tissue

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GLP-1 receptor activation inhibits the activation of hepatic Kupffer cells and infiltrating macrophages, leading to decreased production of pro-inflammatory cytokines such as TNF- and IL-1, thereby attenuating hepatic inflammation ( Preclinical models have shown that GLP-1 analogs suppress hepatic stellate cell activation, the key drivers of fibrogenesis, resulting in reduced collagen deposition and fibrosis ( Clinical trials that investigate dual GLP-1/GIP receptor agonists have presented encouraging evidence for their efficacy and safety in treating MASLD