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92 showed that enzymatically increasing the NADH-to-NAD + conversion exclusively in the mitochondria of HeLa cells improves ETC function, highlighting the importance of maintaining high NAD + levels

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More in-depth research that clarifies the roles of these components of the GST-detoxification system are much needed, in order to produce compounds that have minimal side effects and high GST selectivity

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This step might involve acid-base catalysis by the active-site cysteinyl thiolate (which could explain an effect of the second cysteinyl residue), and/or the conserved lysine residue, yielding GS in analogy to glutathione transferases (Fig

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