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15 : 117132 Smith CD, Gallenstein LG, Layton WJ, Kryscio RJ, Markesbery WR
doi: 10.1111/dom.13804 36 JendleJBirkenfeldALPolonskyWHSilverRUusinarkausKHansenTet al
When Phase I runs faster than Phase II (from enzyme induction, genetic polymorphisms, or cofactor depletion), reactive intermediates accumulate and cause oxidative damage to DNA, lipids, and proteins
This work was supported by the National Natural Science Foundation of China (U23A20501, 82404816), the key research and development plan projects of Heilongjiang Province (2022ZX02C04), the Guangdong Basic and Applied Basic Research Found Project (2023A1515110703), the Traditional Chinese Medicine Bureau Of Guangdong Province (20254061), the State Key Laboratory of Dampness Syndrome of Chinese Medicine (SZ2021ZZ49, SZ2022KF16), the Second Affiliated Hospital of Guangzhou University of Chinese Medicine(YN2024GZRPY017)
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