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PGC-1 is a master transcriptional co-activator of numerous genes involved in mitochondrial biogenesis
Reisch, A., Runser, A., Arntz, Y., Mly, Y
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This is not the best way
& Berndt, K
Excessive production of ROS, largely arising from mitochondrial oxidative phosphorylation, is a major driver of oxidative damage and mitochondrial dysfunction processes that correlate with MDD symptom severity, illness chronicity, cognitive impairment, and poor antidepressant response [138, 139]
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