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Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243
Conversely, those in sunny climates might intensify during summer to support antioxidant defenses against UV-induced oxidative stress
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Layer V cortical neurons require microglial support for survival during postnatal development
