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SURMOUNT-5 data (2025) shows tirzepatide achieves approximately 47% greater average weight loss than semaglutide over a comparable period

"GLP-1 agonists are not benign medications, and they have side effects, Wojeck says

They are also not used in people who are pregnant or breastfeeding, and caution is taken with patients who have a history of pancreatitis

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[2] For people who prioritize a needle-free routine, Rybelsus serves as a compelling Ozempic alternative, offering comparable glycemic and weight-loss benefits