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Data from the STEP-1 and SURMOUNT-1 trails suggest that up to 45% of total weight loss may derive from skeletal muscle, leading to concerns about sarcopenia

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

GLP-1 secretion may be normal or modestly reduced in type 2 diabetes, with considerable variability across studies

A two-stage, single-arm, phase II study of EGCG-enriched green tea drink as a maintenance therapy in women with advanced s Zheng XX, Xu YL, Li SH, Hui R, Wu YJ, Huang XH

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However, it works by mimicking natural GHRH to promote a more physiological release of GH over time