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The NDA for Wegovy was submitted in December 2020, before the pivotal trial was even published

These statements appear inconsistent

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GSH synthesis catalyzed sequentially by two cytosolic enzymes, -glutamyl-cysteine synthetase (GCS) and GSH synthetase is part of virtually all cell types, and the liver is the major GSH producer and exporter

[5] [6] The frequency appears comparable to other GLP-1 agonists, though longer-term post-marketing data are still accumulating

Mild cold sensitivity is generally a benign physiological response to weight loss rather than a dangerous side effect