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One key player in this response is posited to be MST1, a protein that increases its activity in the presence of oxidative stress

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It takes weeks, which is exactly why the clinical protocols build in four-week intervals between dose increases

Following this, vitamin B 12 serves as a co-enzyme for methionine synthase, the essential enzyme facilitating the transfer of a methyl group from 5-methyl-tetrahydrofolate to Hcy, thereby promoting the regeneration of Met (Preynat et al., 2009)

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