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So, whats the bottom line
Actual patient
PSM, Propensity Score Matching
A randomized controlled trial in AD patients reported no significant adverse effects, with irritability being the most common complaint [17]
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This partial agonism is intrinsic to orforglipron's binding mode: as an allosteric agonist occupying a smaller binding pocket with fewer receptor contacts than peptide ligands, it stabilizes a receptor conformation that is somewhat less efficient at coupling to Gs proteins than the fully peptide-activated state
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