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Perron U, Grassi E, Chatzipli A, Viviani M, Karakoc E, Trastulla L, et al
Studies also show that giving exogenous melatonin to animals also increases survival time in a similar manner to calorie restriction.[ref] Not all studies show this, so it may be species-specific
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It induces MCP-1 mediated inflammatory signals and pSMAD2/3 mediated profibrotic signal pathway activation, increasing the expression of the matrix gene decorin from glucose response elements and reducing fibronectin, ultimately leading to VSMC proliferation and hypertrophy [60]
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These dynamic metabolic variations directly influence drug distribution, target expression, and therapeutic response, posing significant challenges to the development of effective personalized treatment strategies [15, 18, 21]
