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No official contraindication exists, as both work through entirely different mechanisms and metabolic pathways
The FDA website hosts prescribing information for Mounjaro (tirzepatide for diabetes) and Zepbound (tirzepatide for weight loss)
These complementary mechanisms suggest potential synergy
- People with poorly controlled bone-turnover conditions, until the dose-dependent osteocalcin changes seen in the 26-week rat study are better understood
This isnt practical for individuals who suffer from chronic B12 deficiency or frequently deplete the entirety of their B12 stores
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