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Interestingly, a recent study has also identified ERMCSs as required for lipid radical transfer from mitochondria to the ER to reduce mitochondrial oxidative stress 87 , which could represent another mechanism stimulated by ERMCS-localised GLP-1R to enhance -cell survival under glucolipotoxic conditions

A., & Stroup, T

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Holmes, G

For obesity management , GLP-1 receptor agonists such as semaglutide 2.4mg (Wegovy) are recommended by NICE (TA875) only through specialist weight management services for people with specific BMI thresholds and weight-related complications