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GLP-1 medications are best if taken long-term, but shortages, price, and side effects like GI discomfort are potential barriers for some
Unlike some diabetes medications such as SGLT2 inhibitors, which work by causing the kidneys to remove excess glucose through urine, Ozempic functions through an entirely different mechanism
Regular injections improve overall emotional well-being
Additionally, a study on healthcare workers investigated CLOCK, BMAL1, and PER1 polymorphisms in relation to hypertension, finding that the CLOCK rs1801260 GG and BMAL1 rs11022775 TT genotypes were associated with a reduced risk of hypertension, whereas PER1 rs2735611 showed no significant association, highlighting how circadian gene variants may influence cardiovascular outcomes in NS workers 218
In the future, this could lead to an expansion in the range of indications (clinical uses) that GLP-1RAs are licensed and used for
The peptide terminates with an amide group rather than a free acid, enhancing stability and reducing enzymatic degradation in laboratory conditions
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