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As the hepatic T4 to T3 conversion is stimulated in response to feeding 16 , the role of hepatic TH signaling in the metabolic response to nutrient ingestion has been of interest

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The phase 2 data got published in the New England Journal of Medicine

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4,5 The FDA approval of Wegovy was based on the results of the STEP ( S emaglutide Tr eatment E ffect in P eople with Obesity) clinical trial program, which included four phase 3a clinical trials involving approximately 4,500 patients