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Seek medical attention if you experience severe or worsening weakness that interferes with daily activities, signs of dehydration (decreased urination, dizziness, confusion), symptoms of low blood sugar, persistent vomiting preventing adequate oral intake, or severe abdominal pain that could indicate pancreatitis

Retatrutide is a multi-functional peptide drug that acts as an agonist of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

The two Graf reviews compiled this early animal-model literature alongside distribution and metabolism data (PMID 6145137)

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