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Other contributors include charge and hydrophobicity (which affect tissue distribution and reabsorption), the route of administration (subcutaneous injection creates a slow-release depot compared with intravenous dosing), and formulation

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Histological examination using hematoxylin and eosin (HE) staining revealed disorganized arrangement of epithelial cells, irregular duct and acinar morphology, and varying degrees of increased epithelial thickness, characterized by papillary or villous projections into the lumen, resulting in a proliferative folding appearance (Fig

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