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Orforglipron and its small-molecule successors open the door to crystalline form patents as well as process/synthesis, key intermediate, oral formulation, prodrug, and stereochemistry patents
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doi: 10.2337/dc23-0872 19 SawamuraTMizoguchiROhmoriAKometaniMYonedaTKarashimaS
If patients experience persistent nausea or inability to maintain adequate oral intake, they should contact their prescribing clinician, as dose adjustment may be necessary
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