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Wegovy has more cardiovascular outcomes data

These agents activate AMP-activated protein kinase signaling, leading to suppression of mammalian target of rapamycin complex 1 activity and reduced expression of pro-inflammatory cytokines and adhesion molecules [29]

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And unlike Rybelsus, which has very strict rules around when and how to take it, Orforglipron is expected to have much simpler dosing requirements