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We think that, by modulating cerebrospinal fluid pressure and reducing intracranial venous sinuses compression, these drugs produce a decrease in the release of calcitonin gene-related peptide (CGRP), a key migraine-promoting peptide, Dr Braca said

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However, some patients report better tolerability at equivalent weight loss levels, possibly due to the balancing effects of GIP

Proc Natl Acad Sci U S A 106: 1285-1290

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That rule has been applied in recent years to popular GLP-1 weight-loss medications, although its unclear how long the approvals will last