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Combining the induction of ferroptosis with the inhibition of defense mechanisms, such as AIFM2 or NFE2L2 inhibitors, holds promise as a potential treatment strategy for pancreatic cancers with KRAS mutations

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It also induces weight loss, indirectly reducing inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-), which are implicated in neurodegenerative changes

Considering that aromatizable testosterone, but not DHT, replacement in GDX male ARKO mice improved femur BMD, it suggests that males too rely on estrogen-ER signaling for bone maintenance, yet not as critically as females, who experience little perturbance in bone morphology as a response to lost AR