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Notably, hydrogen bonds, which account for the high affinity, are formed between DEHP and proteins due to the four hydrogen bond receptors of the carboxyl groups, including ASN-51 of HSP90AA1, ARG-24 of IL6, LYS-54 of MAPK1, GLN-20 of BCL2, GLN-20 of EP300, ARG-207 of CASP3, GLN-68 and THR-45 of ERBB2, LYS-87 of BCL2L1, and ARG-112 of GRB2

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For many, its a combination of both over time

doi: 10.1111/j.1574-6976.1999.tb00393.x 187 ReaM

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Pancreatitis and pancreatic cancer were reported in some studies but not in large CVOTs with relatively long duration of follow-up