Daily D, Vlamis-Gardikas A, Offen D, Mittelman L, Melamed E, Holmgren A et al
Regarding the inconsistency of the aforementioned results, we hypothesize that it may be attributed to the following factors: (1) Drug structure and receptor binding specificity: Inherent variations exist in the molecular structure, half-life, and receptor binding efficacy among different GLP-1RAs, which directly determine their functional selectivity for atrial cardiomyocytes
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The primary endpoint was change from baseline in HbA1c at week 40, using a non-inferiority margin of 03% for Orforglipron versus Dapagliflozin
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