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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+
Both tests came back negative: AOD9604 did not cause mutations in bacteria and did not damage chromosomes in mammalian cells
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In rare therapeutic cases, they may contribute to rapid weight changes, but not commonly in regular dosing
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