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Lean muscle loss is a genuine tradeoff Research consistently shows that roughly 25 to 40 percent of the weight lost on GLP-1 medications is lean body mass, not fat
PMID: 41931049
Zhang X, Wang S, Wang H, Huang X,Chen Z, Xu P, Sun G,Xu JLJ, Xu Z
This steady level is important for appetite control and weight loss
Private prescriptions for weight loss medication are available but can cost hundreds of pounds per month, making long-term use unaffordable for most people
The STEP 1 trial (Wilding et al., The Lancet, 2021) showed an average weight loss of 14.9% over 68 weeks versus 2.4% in the placebo group a landmark result that established semaglutide as the benchmark for GLP-1 weight loss
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