When glutathione is depleted or GPX4 is inhibited, lipid peroxides accumulate and drive ferroptosis, so GSH and GPX assays report on the cell's ferroptosis defence
2.2.3 Others Metformin influences the production of advanced glycation end products (AGEs) and the generation of ROS through the activation of AMPK, inhibition of the receptor for advanced glycation end products/nuclear factor kappa B (RAGE/NF-B) signaling pathway, and modulation of gene expression
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Deng M, Wu X, Duan X, Xu J, Yang X, Sheng X, et al
Peptides are small proteins, meaning that they are composed of amino acid building blocks that are linked by peptide bonds, but they are fairly small in size
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