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Charge-reversal nano-drug delivery systems in the tumor microenvironment: mechanisms, challenges, and therapeutic applications
However, pathologic conditions activate microglia to increase cytokine production, resulting in either a pro-inflammatory or anti-inflammatory phenotype, classically defined as M1 and M2, respectively, (Woodburn et al., 2021
doi: 10.3168/jds.S0022-0302(88)79584-3 69 KitadaM.XuJ.OguraY.MonnoI.KoyaD
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They aren't alternatives to each other they're complementary research tools that address different research questions
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