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Seiwerth and colleagues (Inflammopharmacology, 1999) documented effects on angiogenic growth factor pathway signalling, and subsequent work has expanded characterisation to include VEGF receptor 2 upregulation, endothelial cell migration in capillary-formation assays, and improved healing in ischemia-reperfusion preparations
Although these findings have generated considerable interest, most of the available evidence comes from laboratory and animal studies rather than large human clinical trials
Analysis convention: the eloralintide figures cited above are efficacy-estimand results, which model outcomes as if participants stayed on treatment
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