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No intermediate observations between baseline and week 104 were used in the analysis 59
L., & Anton, S
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In the first step, branch lengths were estimated by maximum likelihood using CODEML 83 , which calculated the gradient and Hessian of the likelihood function at the maximum likelihood estimates
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This small molecule, dihexa, penetrates the BBB, induces spinogenesis/synaptogenesis at picomolar concentrations [70] , and is slowly cleared from the blood (plasma stability t 1/2 = 335.5 min) [73]
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