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Both medications produce similar rates of musculoskeletal complaints in clinical trials, with body aches reported in roughly 1-5% of users across both drug classes

Mean (standard deviation [SD]) BMI was 37.2 (SD, 8.0) kg/m for IXE+TZP and 38.4 (SD, 7.4) for IXE

If the allodynia is severe enough to significantly impair quality of life, temporary discontinuation allows the nervous system to reset