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The full therapeutic dose may not be reached until 16 to 20 weeks after initiation, which delays maximal efficacy but improves tolerability and treatment adherence
K., Kalvala, A
Amenorrhea can happen when the body experiences a large and sudden weight loss, which may signal to the brain that it is not a good time for reproduction
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Supporting these in vivo observations, our in vitro studies using isolated cardiac fibroblasts also demonstrated that linagliptin inhibits aldosterone-induced TRAF3IP2 expression, oxidative stress, inflammatory cytokine expression, and cardiac fibroblast activation and migration
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