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In contrast, PWA mice display overt metabolic perturbations, including overweight and impaired glucose homeostasis 46 , and may mimic the canonical human phenotype A of PCOS linked to hyperandrogenism, anovulatory cycles, and polycystic ovarian morphology 45

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The blood samples were taken at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 14, 16, 20, 24 hours after dose administration