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Microneedling's limitation as a delivery tool is that it does not supply any specific regenerative signal it opens channels and provokes healing, but what fills those channels depends on what you apply

Engineering approaches for exosome cargo loading and targeted delivery: biological versus chemical perspectives

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10.1007/BF00711382

Together, these shifts create a metabolic environment that substantially increases vulnerability to cardiometabolic disease (Van der Leeuw et al., 2013)