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A 2026 network meta-analysis including over 13,000 participants found that tirzepatide intervention produced significantly better results than semaglutide across multiple measures, not just weight loss, but also improvements in blood sugar control and metabolic health markers
Jagtap U, Bapat VA
doi: 10.1016/j.celrep.2020.107768 79 Mietlicki-BaaseEGLiberiniCGWorkingerJLBonaccorsoRLBornerTReinerDJet al
Still, Apovian says that the potential suggested by the retatrutide results is "really fantastic," although she adds that having a variety of weight loss medications is important
Glucagon-like peptide 1: a potent glycogenic hormone
Bone resorption is unchanged by liraglutide in type 2 diabetes patients: A randomised controlled trial
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