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Such platforms allow synergistic actionfor instance, curcumin can sensitize resistant cancer cells to paclitaxel, while nanocarriers ensure both agents reach the tumor simultaneously

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The higher dose in the second half of the cycle is designed to reinforce the collagen synthesis, sirtuin activation, and anti-inflammatory pathways initiated in Phase 1

In addition to treating diseases by modulating palmitoylation-related enzymes, therapeutic agents can target specific palmitoylated cysteine residues, such as C176/178, H-151, NO2-FAs or nitrofuran molecules, which can block STING palmitoylation modification by covalently modifying the Cys91 residue of STING, inhibiting type I interferon signaling, and providing a new therapeutic target for STING-associated diseases by blocking STING palmitoylation and inhibiting type I interferon signaling (103, 251)