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Description

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Safety of Synthetic Lergothioneine (Ergoneine) as a Novel Food Pursuant to Regulation (EC) No 258/97

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Why that selectivity exists at the receptor level isnt entirely settled it may reflect biased agonism, where the specific binding geometry favors the somatotroph signaling pathway over the corticotroph one, even though both cell populations express GHSR-1a

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After 12 h incubation, cells were treated with PBS, Ru(II)-OH, NP2, or NP4 for 24 h (Ru 10 M), washed with PBS and incubated with Annexin/PI reagent in the dark for 15 min at 25 C

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