Although an excess of ROS may lead to a harmful effect on oocytes, the presence of ROS derived from mitochondrial respiration is necessary for certain cell signaling pathways involved in folliculogenesis, oocyte maturation, embryogenesis and implantation 58
FT was measured using the COmprehensive Score for FT (COST), a validated 12-item measure on financial stressors of cancer care
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Advanced paternal age is associated with a decline in function of the male reproductive system, sperm quality, and fertility owing to age-associated accumulation of DNA damage and mutations or age-associated germ cell loss, which is further correlated with paternal contribution to chromosomal damage and genetic health problems in the children
A key focus here should be to provide a clear mechanistic explanation for why USP8 drives distinct EGFR downstream pathway activation in these two settings