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Although these therapies provide significant clinical benefits, substantial unmet needs remain, creating opportunities for further innovation

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Calder, 2020

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3 Strategies like enteric coatings to bypass gastric acid, local pH modulation and enzyme inhibitors to deactivate intestinal proteases, muco-penetrating or muco-adhesive carriers, and transient permeation enhancers to increase membrane fluidity are used to mitigate these barriers