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GLP-1 acts on homeostatic hunger circuits in the hypothalamus and brainstem

Study design RCTs, systematic reviews, meta-analyses, observational studies, and mechanistic preclinical studies

Hypersensitivity Reactions Inform patients that serious hypersensitivity reactions have been reported during postmarketing use of semaglutide, the active ingredient in WEGOVY

GLP-1 also affects these factors (except sex and medication)

The most common barriers are lack of awareness and provider reluctance to complete paperwork

This breakthrough opens new opportunities for improved treatment adherence, formulary positioning, and the potential decreased reliance on mechanical devices