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doi: 10.1038/s42255-020-0209-6 132 DingXSaxenaNKLinSGuptaNAAnaniaFA
The retatrutide triple agonist GLP-1 GIP glucagon mechanism works through three parallel axes: GLP-1 receptor activation: Stimulates glucose-dependent insulin secretion from pancreatic beta cells, suppresses glucagon release from alpha cells, slows gastric emptying, and reduces appetite signalling in the hypothalamus
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appetite suppression through MC4R reduces food intake
NHS access is expected later in 2026 following a NICE health technology assessment
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