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Mitochondria contain 1015% of total GSH, and the concentration of GSH in mitochondria is similar to that of the cytoplasmic matrix [57, 58]
As a small molecule that is highly prone to reacting with ROS, glutathione is at the core of a handful of different oxidative stress management systems.* In each of these systems, glutathione acts as a carrier of ROS
doi:10.1093/ajcn/76.5.1151S 7
Obesity itself is considered a chronic low-grade inflammatory state, often accompanied by significant oxidative stress
J., Allbritton, N
Thiamine (B1) deficiency, for instance, can cause Wernicke-Korsakoff syndrome, a potentially fatal neurological disorder
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