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Michael Madaio, nephrologist, chair emeritus of the MCG Department of Medicine and the studys co-corresponding author

A perspective

That is an important framing for anyone tempted to treat it as a shortcut: even in the animal work that generates the interest, the compound is one input alongside energy balance, not a replacement for it

Factors such as symptom severity, imaging findings, activity goals, medical history, and previous treatments all contribute to determining the most appropriate management strategy

Its deficiency can impact immunity, cognition, and even heart function

Researchers have also examined DSIP-related markers in Cushing syndrome, a disorder involving chronically elevated cortisol levels