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However, severe side effects are rare, and most side effects can be managed by starting at a lower dose and gradually increasing as tolerated
[63] encompassing 1895 patients with T2DM reported a greater reduction in HbA1c, body weight, FPG, systolic blood pressure, BMI, and low-density lipoprotein cholesterol in a combination therapy group, compared to monotherapy with either GLP-1RA or SGLT-2i
The availability of the first oral GLP-1RA not only expands the repertoire of highly effective treatments for patients with T2D but may also mark the beginning of a new era for oral peptides
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