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Accordingly, mechanistic interpretations should not be construed as confirmed clinical mechanisms but as explanatory frameworks requiring validation in mechanistic human studies
doi: 10.1016/j.lwt.2020.110759 215
Scientists and journalists share a core belief in questioning, observing and verifying to reach the truth
This critical substitution provides steric hindrance against dipeptidyl peptidase-4 (DPP-4) degradation
However, the leading theory behind PD pathogenesis is the accumulation of alpha-synuclein aggregates within cells, which trigger neuroinflammation and neuronal apoptosis (Kim et al., 2019)
At least a third of people taking GLP-1s report feeling nauseous, while others also experience constipation and gastrointestinal distress
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