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Vitamin B (pyridoxine), when chronically taken in gram quantities, is known to cause a sensory neuropathy, numbness and tingling in the extremities, but the amount of B in this formula (2 mg per mL) is far below such neurotoxic levels

Hours 24-48: 41% report "starting to feel different," described as "less heavy," "clearer thinking," or "easier to get out of bed." Hours 48-72: Peak onset window

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However, the ideal frequency can vary based on the severity of the deficiency and your response to treatment

A small percentage, around 12% of the dose, is absorbed passively across the gut lining without IF

318 (6), G1042G1053